[HTML][HTML] Scavenger receptors class AI/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in …
VV Kunjathoor, M Febbraio, EA Podrez… - Journal of Biological …, 2002 - ASBMB
Modification of low density lipoprotein (LDL) can result in the avid uptake of these
lipoproteins via a family of macrophage transmembrane proteins referred to as scavenger
receptors (SRs). The genetic inactivation of either of two SR family members, SR-A or CD36,
has been shown previously to reduce oxidized LDL uptakein vitro and atherosclerotic
lesions in mice. Several other SRs are reported to bind modified LDL, but their contribution
to macrophage lipid accumulation is uncertain. We generated mice lacking both SR-A and …
lipoproteins via a family of macrophage transmembrane proteins referred to as scavenger
receptors (SRs). The genetic inactivation of either of two SR family members, SR-A or CD36,
has been shown previously to reduce oxidized LDL uptakein vitro and atherosclerotic
lesions in mice. Several other SRs are reported to bind modified LDL, but their contribution
to macrophage lipid accumulation is uncertain. We generated mice lacking both SR-A and …