[HTML][HTML] The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin Cytoskeleton, Rho family GTPases, and myosin ATPase …
SW Sakr, RJ Eddy, H Barth, F Wang… - Journal of Biological …, 2001 - ASBMB
A key cellular event in atherogenesis is the interaction of macrophages with lipoproteins in
the subendothelium. In vivo, these lipoproteins are bound to matrix and often aggregated,
yet most cell-culture experiments explore these events using soluble monomeric
lipoproteins. We hypothesized that the internalization and degradation of matrix-retained
and aggregated low density lipoprotein (LDL) by macrophages may involve the actin-myosin
cytoskeleton in a manner that distinguishes this process from the endocytosis of soluble …
the subendothelium. In vivo, these lipoproteins are bound to matrix and often aggregated,
yet most cell-culture experiments explore these events using soluble monomeric
lipoproteins. We hypothesized that the internalization and degradation of matrix-retained
and aggregated low density lipoprotein (LDL) by macrophages may involve the actin-myosin
cytoskeleton in a manner that distinguishes this process from the endocytosis of soluble …