[HTML][HTML] TAT fusion proteins containing tyrosine 42-deleted IκBα arrest osteoclastogenesis
Y Abu-Amer, SF Dowdy, FP Ross, JC Clohisy… - Journal of Biological …, 2001 - ASBMB
In most circumstances, NF-κB, which is essential for osteoclastogenesis, is activated
following serine 32/36 phosphorylation of its cytosolic inhibitory protein, IκBα. In contrast to
other cell types, IκBα, in bone marrow macrophages (BMMs), which are osteoclast
precursors, is tyrosine-phosphorylated by c-Src kinase. To address the role of IκBα
phosphorylation in osteoclastogenesis, we generated TAT fusion proteins containing wild-
type IκBα (TAT-WT-IκB), IκBα lacking its NH 2-terminal 45 amino acids (TAT-IκB 46–317) …
following serine 32/36 phosphorylation of its cytosolic inhibitory protein, IκBα. In contrast to
other cell types, IκBα, in bone marrow macrophages (BMMs), which are osteoclast
precursors, is tyrosine-phosphorylated by c-Src kinase. To address the role of IκBα
phosphorylation in osteoclastogenesis, we generated TAT fusion proteins containing wild-
type IκBα (TAT-WT-IκB), IκBα lacking its NH 2-terminal 45 amino acids (TAT-IκB 46–317) …