The role of cytokine networks in the local liver injury following hepatic ischemia/reperfusion in the rat
LM Colletti, SL Kunkel, A Walz, MD Burdick… - Hepatology, 1996 - journals.lww.com
The liver is highly susceptible to a number of pathological insults, including
ischemia/reperfusion injury. We have previously employed an animal model of hepatic
ischemia/reperfusion injury, and have shown that this injury induces the production and
release of hepatic-derived tumor necrosis factor α (TNF-α), which mediates, in part, local
liver injury following hepatic reperfusion. In the present study, we have extended these
previous observations to assess whether an interrelationship exists between TNF-α and the …
ischemia/reperfusion injury. We have previously employed an animal model of hepatic
ischemia/reperfusion injury, and have shown that this injury induces the production and
release of hepatic-derived tumor necrosis factor α (TNF-α), which mediates, in part, local
liver injury following hepatic reperfusion. In the present study, we have extended these
previous observations to assess whether an interrelationship exists between TNF-α and the …