[HTML][HTML] The nuclear δB isoform of Ca2+/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytes
MT Ramirez, XL Zhao, H Schulman… - Journal of Biological …, 1997 - ASBMB
Cultured neonatal ventricular myocytes display features of myocardial hypertrophy including
increased cell size, myofilament organization, and reexpression of the embryonic gene for
atrial natriuretic factor (ANF). KN-93, an inhibitor of multifunctional Ca 2+/calmodulin-
dependent protein kinase (CaM kinase II), blocked the induction of these responses by the α
1-adrenergic receptor agonist phenylephrine, whereas its inactive analog KN-92 did not. To
directly determine whether CaM kinase II could regulate ANF gene expression, we …
increased cell size, myofilament organization, and reexpression of the embryonic gene for
atrial natriuretic factor (ANF). KN-93, an inhibitor of multifunctional Ca 2+/calmodulin-
dependent protein kinase (CaM kinase II), blocked the induction of these responses by the α
1-adrenergic receptor agonist phenylephrine, whereas its inactive analog KN-92 did not. To
directly determine whether CaM kinase II could regulate ANF gene expression, we …