Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction
M Hongo, EM Sentianin, N Tanaka, L Mao… - Journal of Cardiac …, 1998 - Elsevier
BACKGROUND:: Recombinant human growth hormone (rhGH) has shown beneficial effects
on cardiac function after myocardial infarction (MI) in rats. High-dose angiotensin II (AT1)
receptor blockade in normal rats inhibited the hypertrophic effect of growth hormone (GH),
therefore we investigated whether GH effects after MI would be enhanced by giving it in
sequence after remodeling had been inhibited by prior AT1 blockade (losartan, L).
METHODS AND RESULTS:: Rats given losartan for 10 weeks after MI followed by rhGH for …
on cardiac function after myocardial infarction (MI) in rats. High-dose angiotensin II (AT1)
receptor blockade in normal rats inhibited the hypertrophic effect of growth hormone (GH),
therefore we investigated whether GH effects after MI would be enhanced by giving it in
sequence after remodeling had been inhibited by prior AT1 blockade (losartan, L).
METHODS AND RESULTS:: Rats given losartan for 10 weeks after MI followed by rhGH for …