Upregulation of type X collagen expression in osteoarthritic cartilage
K von der Mark, S Frischholz, T Aigner… - Acta Orthopaedica …, 1995 - Taylor & Francis
K von der Mark, S Frischholz, T Aigner, F Beier, J Belke, S Erdmann, H Burkhardt
Acta Orthopaedica Scandinavica, 1995•Taylor & FrancisJoint destruction of articular cartilage in osteoarthritis and rheumatoid arthritis is heralded by
surface fibrillation, loss of proteoglycans from the articular surface and increasing hydration
and softening of the cartilage matrix (Sokoloff 1982). These initial changes are followed by
chondrocyte proliferation and formation of cell clusters and extensive remodeling of the
cartilage matrix, ie massive degradation and synthesis of new, but partially altered cartilage
components.
surface fibrillation, loss of proteoglycans from the articular surface and increasing hydration
and softening of the cartilage matrix (Sokoloff 1982). These initial changes are followed by
chondrocyte proliferation and formation of cell clusters and extensive remodeling of the
cartilage matrix, ie massive degradation and synthesis of new, but partially altered cartilage
components.
Joint destruction of articular cartilage in osteoarthritis and rheumatoid arthritis is heralded by surface fibrillation, loss of proteoglycans from the articular surface and increasing hydration and softening of the cartilage matrix (Sokoloff 1982). These initial changes are followed by chondrocyte proliferation and formation of cell clusters and extensive remodeling of the cartilage matrix, i.e. massive degradation and synthesis of new, but partially altered cartilage components.
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