[CITATION][C] Idiopathic myelofibrosis: a review
H Hasselbalch - European journal of haematology, 1990 - Wiley Online Library
H Hasselbalch
European journal of haematology, 1990•Wiley Online LibraryThe designation 'idiopathic'myelofibrosis (IMF) denotes a primary bone marrow disease in
which the normal haematopoietic bone marrow cells for unknown reasons are progressively
replaced by connective tissue (1). In many (and probably most) cases, IMF is a clonal
myeloproliferative disorder, in which the bone marrow fibrosis develops secondarily to the
myeloproliferative process, analogous to the reactive fibrosis following other neoplastic
diseases (2). Several cases have been published in which bone marrow fibrosis and a …
which the normal haematopoietic bone marrow cells for unknown reasons are progressively
replaced by connective tissue (1). In many (and probably most) cases, IMF is a clonal
myeloproliferative disorder, in which the bone marrow fibrosis develops secondarily to the
myeloproliferative process, analogous to the reactive fibrosis following other neoplastic
diseases (2). Several cases have been published in which bone marrow fibrosis and a …
The designation ‘idiopathic’myelofibrosis (IMF) denotes a primary bone marrow disease in which the normal haematopoietic bone marrow cells for unknown reasons are progressively replaced by connective tissue (1). In many (and probably most) cases, IMF is a clonal myeloproliferative disorder, in which the bone marrow fibrosis develops secondarily to the myeloproliferative process, analogous to the reactive fibrosis following other neoplastic diseases (2).
Several cases have been published in which bone marrow fibrosis and a clinical syndrome resembling IMF developed under the influence of various leukaemogenic agents, eg benzene, X-rays and thorotrast administration. An association between virus infection and the development of myelofibrosis has also been described, and in some patients immu-nological mechanisms may be involved (3). Deficiency of vitamin D is occasionally followed by a clinical and histological picture, which strongly mimics that of IMF (4).
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