[HTML][HTML] Overexpression of γ-sarcoglycan induces severe muscular dystrophy: implications for the regulation of sarcoglycan assembly
X Zhu, M Hadhazy, ME Groh, MT Wheeler… - Journal of Biological …, 2001 - ASBMB
The sarcoglycan complex is found normally at the plasma membrane of muscle. Disruption
of the sarcoglycan complex, through primary gene mutations in dystrophin or sarcoglycan
subunits, produces membrane instability and muscular dystrophy. Restoration of the
sarcoglycan complex at the plasma membrane requires reintroduction of the mutant
sarcoglycan subunit in a manner that will permit normal assembly of the entire sarcoglycan
complex. To study sarcoglycan gene replacement, we introduced transgenes expressing …
of the sarcoglycan complex, through primary gene mutations in dystrophin or sarcoglycan
subunits, produces membrane instability and muscular dystrophy. Restoration of the
sarcoglycan complex at the plasma membrane requires reintroduction of the mutant
sarcoglycan subunit in a manner that will permit normal assembly of the entire sarcoglycan
complex. To study sarcoglycan gene replacement, we introduced transgenes expressing …