Mechanisms of glucocorticoid-induced immunosuppression: inhibitory effects on expression of Fc receptors and production of T-cell growth factor
GR Crabtree, S Gillis, KA Smith, A Munck - Journal of Steroid Biochemistry, 1980 - Elsevier
T-cell growth factor, produced by mitogen or antigen-stimulated spleen cells, is necessary
for the proliferation of T-lymphocytes in culture, and may be responsible for clonal expansion
of antigen-responsive T-cells. We have found that treatment of Con A-stimulated rat spleen
cells or human peripheral mononuclear cells with 100 n M dexamethasone inhibited the
production of the growth factor by 95%. This effect was specific for glucocorticoids at
physiologic concentrations. Addition of T-cell growth factor completely reversed the …
for the proliferation of T-lymphocytes in culture, and may be responsible for clonal expansion
of antigen-responsive T-cells. We have found that treatment of Con A-stimulated rat spleen
cells or human peripheral mononuclear cells with 100 n M dexamethasone inhibited the
production of the growth factor by 95%. This effect was specific for glucocorticoids at
physiologic concentrations. Addition of T-cell growth factor completely reversed the …