[HTML][HTML] Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts: a cyclooxygenase-2 mediated pathway
J Davaille, C Gallois, A Habib, L Li, A Mallat… - Journal of Biological …, 2000 - ASBMB
Proliferation of hepatic myofibroblasts (hMF) is central for the development of fibrosis during
liver injury, and factors that may limit their growth are potential antifibrotic agents.
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid with growth-regulating
properties, either via Edg receptors or through intracellular actions. In this study, we
examined the effects of S1P on the proliferation of human hMF. Human hMF expressed
mRNAs for the S1P receptors Edg1, Edg3, and Edg5. These receptors were functional at …
liver injury, and factors that may limit their growth are potential antifibrotic agents.
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid with growth-regulating
properties, either via Edg receptors or through intracellular actions. In this study, we
examined the effects of S1P on the proliferation of human hMF. Human hMF expressed
mRNAs for the S1P receptors Edg1, Edg3, and Edg5. These receptors were functional at …