[HTML][HTML] Apolipoprotein-mediated plasma membrane microsolubilization: role of lipid affinity and membrane penetration in the efflux of cellular cholesterol and …
KL Gillotte, M Zaiou, S Lund-Katz… - Journal of Biological …, 1999 - ASBMB
Lipid-free apolipoprotein (apo) AI contributes to the reverse transport of cholesterol from the
periphery to the liver by solubilizing plasma membrane phospholipid and cholesterol. The
features of the apolipoprotein required for this process are not understood and are
addressed in the current study. Membrane microsolubilization of human fibroblasts is not
specific for apo AI; unlipidated apos A-II, C, and E incubated with the fibroblast monolayers
at a saturating concentration of 50 μg/ml are all able to release cholesterol and phospholipid …
periphery to the liver by solubilizing plasma membrane phospholipid and cholesterol. The
features of the apolipoprotein required for this process are not understood and are
addressed in the current study. Membrane microsolubilization of human fibroblasts is not
specific for apo AI; unlipidated apos A-II, C, and E incubated with the fibroblast monolayers
at a saturating concentration of 50 μg/ml are all able to release cholesterol and phospholipid …