Association of moderate polyglutamine tract expansions in the slow calcium-activated potassium channel type 3 with ataxia
KP Figueroa, P Chan, L Schöls, C Tanner… - Archives of …, 2001 - jamanetwork.com
Background The small-conductance calcium-activated potassium channel gene (hSKCa3)
contains 2 CAG repeats, 1 of which is highly polymorphic. Although this repeat is not
pathologically expanded in patients with schizophrenia, some studies have suggested an
allelic association with schizophrenia. CAG expansions in other genes such as the α1
subunit of a brain-specific P/Q-type calcium channel gene cause spinocerebellar ataxia type
6, whereas the length of the CAG repeat in theRAI1gene modifies the age of onset of …
contains 2 CAG repeats, 1 of which is highly polymorphic. Although this repeat is not
pathologically expanded in patients with schizophrenia, some studies have suggested an
allelic association with schizophrenia. CAG expansions in other genes such as the α1
subunit of a brain-specific P/Q-type calcium channel gene cause spinocerebellar ataxia type
6, whereas the length of the CAG repeat in theRAI1gene modifies the age of onset of …