Sphingosine 1-phosphate signaling in atherosclerosis and vascular biology
K Tamama, F Okajima - Current opinion in lipidology, 2002 - journals.lww.com
K Tamama, F Okajima
Current opinion in lipidology, 2002•journals.lww.comActivated platelets were shown to be the source of S1P in blood [11, 12]. Proteins and lipids
released from activated platelets have long been regarded as enhancing the integrity of
microcirculation in vivo and in vitro [13, 14], and S1P was proposed to be one of the
candidates for this action [15••]. S1P concentration in plasma was reported to be 200±400
nmol/l [16, 17], and S1P accumulated in the lipoprotein fraction, especially in HDL and LDL
fractions, in plasma [17, 18]. Endothelial cells and vascular smooth muscle cells (VSMCs) …
released from activated platelets have long been regarded as enhancing the integrity of
microcirculation in vivo and in vitro [13, 14], and S1P was proposed to be one of the
candidates for this action [15••]. S1P concentration in plasma was reported to be 200±400
nmol/l [16, 17], and S1P accumulated in the lipoprotein fraction, especially in HDL and LDL
fractions, in plasma [17, 18]. Endothelial cells and vascular smooth muscle cells (VSMCs) …
Activated platelets were shown to be the source of S1P in blood [11, 12]. Proteins and lipids released from activated platelets have long been regarded as enhancing the integrity of microcirculation in vivo and in vitro [13, 14], and S1P was proposed to be one of the candidates for this action [15••]. S1P concentration in plasma was reported to be 200±400 nmol/l [16, 17], and S1P accumulated in the lipoprotein fraction, especially in HDL and LDL fractions, in plasma [17, 18].
Endothelial cells and vascular smooth muscle cells (VSMCs) express S1P receptors, and the effects of S1P on the proliferation and migration of these cells have been reported [19±21]. Our understanding of the role of S1P in vascular biology has been increased, and it is becoming clear that S1P plays a regulatory role in the development of atherosclerosis [22±24]. In this review, we discuss the latest findings and developments of S1P research in vascular biology and atherosclerosis.
Lippincott Williams & Wilkins