[HTML][HTML] Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A
Recently, we have shown that shear stress stimulates NO⋅ production by the protein kinase
B/Akt (Akt)-dependent mechanisms in bovine aortic endothelial cells (BAEC)(Go, YM, Boo,
YC, Park, H., Maland, MC, Patel, R., Pritchard, KA, Jr., Fujio, Y., Walsh, K., Darley-Usmar, V.,
and Jo, H.(2001) J. Appl. Physiol. 91, 1574–1581). Akt has been believed to regulate shear-
dependent production of NO⋅ by directly phosphorylating endothelial nitric-oxide synthase
(eNOS) at the Ser 1179 residue (eNOS-S 1179), but a critical evaluation using specific …
B/Akt (Akt)-dependent mechanisms in bovine aortic endothelial cells (BAEC)(Go, YM, Boo,
YC, Park, H., Maland, MC, Patel, R., Pritchard, KA, Jr., Fujio, Y., Walsh, K., Darley-Usmar, V.,
and Jo, H.(2001) J. Appl. Physiol. 91, 1574–1581). Akt has been believed to regulate shear-
dependent production of NO⋅ by directly phosphorylating endothelial nitric-oxide synthase
(eNOS) at the Ser 1179 residue (eNOS-S 1179), but a critical evaluation using specific …