[HTML][HTML] High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in …
A Uittenbogaard, PW Shaul, IS Yuhanna, A Blair… - Journal of Biological …, 2000 - ASBMB
Oxidized LDL (oxLDL) depletes caveolae of cholesterol, resulting in the displacement of
endothelial nitric-oxide synthase (eNOS) from caveolae and impaired eNOS activation. In
the present study, we determined if the class B scavenger receptors, CD36 and SR-BI, are
involved in regulating nitric-oxide synthase localization and function. We demonstrate that
CD36 and SR-BI are expressed in endothelial cells, co-fractionate with caveolae, and co-
immunoprecipitate with caveolin-1. Co-incubation of cells with 10 μg/ml high density …
endothelial nitric-oxide synthase (eNOS) from caveolae and impaired eNOS activation. In
the present study, we determined if the class B scavenger receptors, CD36 and SR-BI, are
involved in regulating nitric-oxide synthase localization and function. We demonstrate that
CD36 and SR-BI are expressed in endothelial cells, co-fractionate with caveolae, and co-
immunoprecipitate with caveolin-1. Co-incubation of cells with 10 μg/ml high density …