[HTML][HTML] Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation
A Blair, PW Shaul, IS Yuhanna, PA Conrad… - Journal of Biological …, 1999 - ASBMB
Hypercholesterolemia-induced vascular disease and atherosclerosis are characterized by a
decrease in the bioavailability of endothelium-derived nitric oxide. Endothelial nitric-oxide
synthase (eNOS) associates with caveolae and is directly regulated by the caveola protein,
caveolin. In the present study, we examined the effects of oxidized low density lipoprotein
(oxLDL) on the subcellular location of eNOS, on eNOS activation, and on caveola
cholesterol in endothelial cells. We found that treatment with 10 μg/ml oxLDL for 60 min …
decrease in the bioavailability of endothelium-derived nitric oxide. Endothelial nitric-oxide
synthase (eNOS) associates with caveolae and is directly regulated by the caveola protein,
caveolin. In the present study, we examined the effects of oxidized low density lipoprotein
(oxLDL) on the subcellular location of eNOS, on eNOS activation, and on caveola
cholesterol in endothelial cells. We found that treatment with 10 μg/ml oxLDL for 60 min …