[HTML][HTML] Biphasic activation of PKBα/Akt in platelets: Evidence for stimulation both by phosphatidylinositol 3, 4-bisphosphate, produced via a novel pathway, and by …
H Banfic, CP Downes, SE Rittenhouse - Journal of Biological Chemistry, 1998 - ASBMB
Stimulation of platelet thrombin receptors or protein kinase C causes fibrinogen-dependent
aggregation that is a function of integrin α IIb β 3 activation. Such platelets rapidly and
transiently form phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P 3) and a small
amount of phosphatidylinositol 3, 4-bisphosphate (PtdIns (3, 4) P 2). After aggregation, a
larger amount of PtdIns (3, 4) P 2 is generated. We report that this latter PtdIns (3, 4) P 2
arises largely through wortmannin-inhibitable generation of PtdIns3P and then …
aggregation that is a function of integrin α IIb β 3 activation. Such platelets rapidly and
transiently form phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P 3) and a small
amount of phosphatidylinositol 3, 4-bisphosphate (PtdIns (3, 4) P 2). After aggregation, a
larger amount of PtdIns (3, 4) P 2 is generated. We report that this latter PtdIns (3, 4) P 2
arises largely through wortmannin-inhibitable generation of PtdIns3P and then …