[HTML][HTML] Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
K Nakatani, DA Thompson, A Barthel, H Sakaue… - Journal of Biological …, 1999 - ASBMB
We measured the insulin-stimulated amount of Akt1, Akt2, and Akt3 enzymatic activities in
four breast cancer cell lines and three prostate cancer cell lines. In the estrogen receptor-
deficient breast cancer cells and the androgen-insensitive prostate cells, the amount of Akt3
enzymatic activity was approximately 20–60-fold higher than in the cells that were estrogen-
or androgen-responsive. In contrast, the levels of Akt1 and-2 were not increased in these
cells. The increase in Akt3 enzyme activity correlated with an increase in both Akt3 mRNA …
four breast cancer cell lines and three prostate cancer cell lines. In the estrogen receptor-
deficient breast cancer cells and the androgen-insensitive prostate cells, the amount of Akt3
enzymatic activity was approximately 20–60-fold higher than in the cells that were estrogen-
or androgen-responsive. In contrast, the levels of Akt1 and-2 were not increased in these
cells. The increase in Akt3 enzyme activity correlated with an increase in both Akt3 mRNA …