Genes coding for tumor antigens recognized by cytolytic T lymphocytes.
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This review of work on mice and humans focuses on the tumour antigens identified in the
authors' laboratory. None of these antigens arises from the product of known oncogenes or
tumour-suppressor genes. The antigens fall into 3 categories: antigens encoded by genes
expressed in tumours but not in most normal tissues, differentiation antigens, and antigens
derived from mutated genes that are expressed ubiquitously.
authors' laboratory. None of these antigens arises from the product of known oncogenes or
tumour-suppressor genes. The antigens fall into 3 categories: antigens encoded by genes
expressed in tumours but not in most normal tissues, differentiation antigens, and antigens
derived from mutated genes that are expressed ubiquitously.
Abstract
This review of work on mice and humans focuses on the tumour antigens identified in the authors' laboratory. None of these antigens arises from the product of known oncogenes or tumour-suppressor genes. The antigens fall into 3 categories: antigens encoded by genes expressed in tumours but not in most normal tissues, differentiation antigens, and antigens derived from mutated genes that are expressed ubiquitously.
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