Timing of initial cereal exposure in infancy and risk of islet autoimmunity

JM Norris, K Barriga, G Klingensmith, M Hoffman… - Jama, 2003 - jamanetwork.com
ContextDietary exposures in infancy have been implicated, albeit inconsistently, in the
etiology of type 1 diabetes mellitus (DM). ObjectiveTo examine the association between
cereal exposures in the infant diet and appearance of islet autoimmunity (IA). DesignBirth
cohort study conducted from 1994 to 2002 with a mean follow-up of 4 years. SettingNewborn
screening for HLA was done at St Joseph's Hospital in Denver, Colo. First-degree relatives
of type 1 DM individuals were recruited from the Denver metropolitan area. ParticipantsWe …