Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project
IM Graham, LE Daly, HM Refsum, K Robinson… - Jama, 1997 - jamanetwork.com
Context.—Elevated plasma homocysteine is a known risk factor for atherosclerotic vascular
disease, but the strength of the relationship and the interaction of plasma homocysteine with
other risk factors are unclear. Objective.—To establish the magnitude of the vascular
disease risk associated with an increased plasma homocysteine level and to examine
interaction effects between elevated plasma homocysteine level and conventional risk
factors. Design.—Case-control study. Setting.—Nineteen centers in 9 European countries …
disease, but the strength of the relationship and the interaction of plasma homocysteine with
other risk factors are unclear. Objective.—To establish the magnitude of the vascular
disease risk associated with an increased plasma homocysteine level and to examine
interaction effects between elevated plasma homocysteine level and conventional risk
factors. Design.—Case-control study. Setting.—Nineteen centers in 9 European countries …