[HTML][HTML] Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies
DG Savage, J Lindenbaum, SP Stabler… - The American journal of …, 1994 - Elsevier
Abstract purpose: Patients with cobalamin (vitamin B12) deficiency usually lack many of the
classic features of severe megaloblastic anemia; because of the low diagnostic specificity of
decreased serum cobalamin levels, demonstrating the deficiency unequivocally is often
difficult. We examined the sensitivity of measuring serum concentrations of methylmalonic
acid and total homocysteine for diagnosing patients with clear-cut cobalamin deficiency and
compared the results with those of patients with clear-cut folate deficiency. patients and …
classic features of severe megaloblastic anemia; because of the low diagnostic specificity of
decreased serum cobalamin levels, demonstrating the deficiency unequivocally is often
difficult. We examined the sensitivity of measuring serum concentrations of methylmalonic
acid and total homocysteine for diagnosing patients with clear-cut cobalamin deficiency and
compared the results with those of patients with clear-cut folate deficiency. patients and …