The potential of bone marrow-derived cells to differentiate to glomerular mesangial cells

T Imasawa, Y Utsunomiya, T Kawamura… - Journal of the …, 2001 - journals.lww.com
Bone marrow stem cells (BMC) develop into hematopoietic and mesenchymal lineages but
have not been known to differentiate into glomerular cells. To investigate whether such
differentiation is possible, a search was made for donor glomerular cells in lethally irradiated
C57BL/6j (B6) mice given transplants of BMC from syngeneic mice transgenic for green
fluorescence protein (GFP)([GFP→ B6] mice). After the recipients of donor BMC manifested
GFP-positive cells in their glomeruli, the numbers of such cells increased markedly, in a time …