[HTML][HTML] The complement regulator factor H binds to the surface protein OspE of Borrelia burgdorferi
J Hellwage, T Meri, T Heikkilä, A Alitalo… - Journal of Biological …, 2001 - ASBMB
Spirochete bacteria of the Borrelia burgdorferi sensu lato complex cause Lyme borreliosis.
The three pathogenic subspecies Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi
sensu stricto differ in their disease profiles and susceptibility to complement lysis. We
investigated whether complement resistance ofBorreliae could be due to acquisition of the
main soluble inhibitors of the alternative complement pathway, factor H and the factor H-like
protein 1. When exposed to nonimmune EDTA-plasma, the serum-resistant B. afzelii and B …
The three pathogenic subspecies Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi
sensu stricto differ in their disease profiles and susceptibility to complement lysis. We
investigated whether complement resistance ofBorreliae could be due to acquisition of the
main soluble inhibitors of the alternative complement pathway, factor H and the factor H-like
protein 1. When exposed to nonimmune EDTA-plasma, the serum-resistant B. afzelii and B …