Signalling through IGF-I and insulin receptors: where is the specificity?
JJ Kim, D Accili - Growth Hormone & IGF Research, 2002 - Elsevier
Receptor tyrosine kinases of the insulin–insulin-like growth factor (IGF) family promote
growth and mediate metabolic signals. Despite their extensive structural homology, genetic
evidence indicates that their physiological functions are distinct. Nevertheless, there is
limited evidence from cell culture systems suggesting that their signalling capabilities differ.
Thus, it remains unclear whether the different physiological roles of insulin and IGF-I
receptors result from intrinsic differences in their abilities to activate distinct signalling …
growth and mediate metabolic signals. Despite their extensive structural homology, genetic
evidence indicates that their physiological functions are distinct. Nevertheless, there is
limited evidence from cell culture systems suggesting that their signalling capabilities differ.
Thus, it remains unclear whether the different physiological roles of insulin and IGF-I
receptors result from intrinsic differences in their abilities to activate distinct signalling …