Replicative senescence of human diploid fibroblasts (HDF) cultured in vitro is characterized
by a progressive and irreversible loss of responsiveness to mitogenic stimulation by serum.
While some constraints have been placed on the nature of HDF senescence, its underlying
molecular mechanism (s) remain obscure. Here, the possibility is considered that defects in
cell cycle-coupled reassembly of repressive chromatin domains may contribute to HDF
senescence. Features of this model are discussed in relation to established models of HDF …