The tumor suppressor protein p16INK4a
M Serrano - Experimental cell research, 1997 - Elsevier
Experimental cell research, 1997•Elsevier
The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links
between cell-cycle control and cancer. The p16INK4agene is frequently inactivated in
human tumors, and inheritance of mutant alleles results in susceptibility to several types of
cancer. p16INK4ais part of a cell-cycle regulatory pathway that converges in the tumor
suppressor protein Rb. The mechanisms that regulate p16INK4aare starting to be
characterized.
between cell-cycle control and cancer. The p16INK4agene is frequently inactivated in
human tumors, and inheritance of mutant alleles results in susceptibility to several types of
cancer. p16INK4ais part of a cell-cycle regulatory pathway that converges in the tumor
suppressor protein Rb. The mechanisms that regulate p16INK4aare starting to be
characterized.
The tumor suppressor protein p16INK4a(inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4agene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16INK4ais part of a cell-cycle regulatory pathway that converges in the tumor suppressor protein Rb. The mechanisms that regulate p16INK4aare starting to be characterized.
Elsevier