A critical role for telomeres in suppressing and facilitating carcinogenesis

SE Artandi, RA DePinho - Current opinion in genetics & development, 2000 - Elsevier
SE Artandi, RA DePinho
Current opinion in genetics & development, 2000Elsevier
Progressive telomere shortening occurs with the division of primary human cells and
activates tumor suppressor pathways, triggering senescence and inhibiting tumorigenesis.
Loss of p53 function, however, allows continued cell division despite increasing telomere
dysfunction and entry into telomere crisis. Recent data suggest that the severe chromosomal
instability of telomere crisis promotes secondary genetic changes that facilitate
carcinogenesis. Reactivation of telomerase stabilizes telomere ends and allows continued …
Progressive telomere shortening occurs with the division of primary human cells and activates tumor suppressor pathways, triggering senescence and inhibiting tumorigenesis. Loss of p53 function, however, allows continued cell division despite increasing telomere dysfunction and entry into telomere crisis. Recent data suggest that the severe chromosomal instability of telomere crisis promotes secondary genetic changes that facilitate carcinogenesis. Reactivation of telomerase stabilizes telomere ends and allows continued tumor growth.
Elsevier