Alveolar epithelial cells express both plasminogen activator and tissue factor: potential role in repair of lung injury

BC Marshall, BR Brown, MA Rothstein, NV Rao… - Chest, 1991 - journal.chestnet.org
The formation of fibrin is a part of the normal tissue repair process. Fibrin not only serves as
a hemostatic barrier and limiting factor in the exudative process, but also provides a matrix
for the tissue repair that follows injury. The plasmin/plasminogen activator system is a key
component in the fibrinolysis that accompanies tissue repair. 1 The adult respiratory distress
syndrome (ARDS) is a common medical problem associated with a high mortality.
lntraalveolar fibrin deposition is a prominent feature of the early phase of this syndrome.• …