[HTML][HTML] Critical role of tumor necrosis factor-α and NF-κB in interferon-γ-induced CD40 expression in microglia/macrophages
VT Nguyen, EN Benveniste - Journal of Biological Chemistry, 2002 - ASBMB
CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 expression
on antigen-presenting cells (including macrophages and microglia) is crucial for T-cell
activation. Aberrant expression of CD40 has been associated with autoimmune
inflammatory diseases such as multiple sclerosis and rheumatoid arthritis. We have recently
shown that the cytokine interferon (IFN)-γ is the most potent inducer of CD40 expression in
macrophages and microglia, and this induction is mediated by the IFN-γ-activated …
on antigen-presenting cells (including macrophages and microglia) is crucial for T-cell
activation. Aberrant expression of CD40 has been associated with autoimmune
inflammatory diseases such as multiple sclerosis and rheumatoid arthritis. We have recently
shown that the cytokine interferon (IFN)-γ is the most potent inducer of CD40 expression in
macrophages and microglia, and this induction is mediated by the IFN-γ-activated …