Telomere states and cell fates

EH Blackburn - Nature, 2000 - nature.com
EH Blackburn
Nature, 2000nature.com
Telomere length has frequently been used as a means to predict the future life of cells. But
by itself it can be a poor indicator of ageing or cell viability. What, then, is the important
property of a telomere? Here recent findings are integrated into a new, probabilistic view of
the telomere to explain how and when it can signal not only its own fate but also that of a
cell.
Abstract
Telomere length has frequently been used as a means to predict the future life of cells. But by itself it can be a poor indicator of ageing or cell viability. What, then, is the important property of a telomere? Here recent findings are integrated into a new, probabilistic view of the telomere to explain how and when it can signal not only its own fate but also that of a cell.
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