[HTML][HTML] Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced …
V Gorbunova, A Seluanov, OM Pereira-Smith - Journal of Biological …, 2002 - ASBMB
Cells subjected to sub-lethal doses of stress such as irradiation or oxidative damage enter a
state that closely resembles replicative senescence. What triggers stress-induced premature
senescence (SIPS) and how similar this mechanism is to replicative senescence are not well
understood. It has been suggested that stress-induced senescence is caused by rapid
telomere shortening resulting from DNA damage. In order to test this hypothesis directly, we
examined whether overexpression of the catalytic subunit of human telomerase (hTERT) …
state that closely resembles replicative senescence. What triggers stress-induced premature
senescence (SIPS) and how similar this mechanism is to replicative senescence are not well
understood. It has been suggested that stress-induced senescence is caused by rapid
telomere shortening resulting from DNA damage. In order to test this hypothesis directly, we
examined whether overexpression of the catalytic subunit of human telomerase (hTERT) …