In vivo antioxidant role of glutathione peroxidase: evidence from knockout mice
XG Lei - Methods in enzymology, 2002 - Elsevier
Cellular glutathione peroxidase (glutathione: H 2 O 2 oxidoreductase, EC 1.11. 1.9, GPX1)
was initially found in erythrocytes by Mills 1 in 1957, when Schwarz and Foltz 2 showed the
nutritional essentiality of selenium (Se) in rats. These two important findings were merged in
1973 by the identification of GPX1 as a selenium-dependent enzyme. 3, 4 This milestone
discovery signified the beginning of a new era of selenium biology, followed by biochemical
characterizations of the GPX1 enzyme. 5, 6, 7 After the first GPX1 gene was cloned by …
was initially found in erythrocytes by Mills 1 in 1957, when Schwarz and Foltz 2 showed the
nutritional essentiality of selenium (Se) in rats. These two important findings were merged in
1973 by the identification of GPX1 as a selenium-dependent enzyme. 3, 4 This milestone
discovery signified the beginning of a new era of selenium biology, followed by biochemical
characterizations of the GPX1 enzyme. 5, 6, 7 After the first GPX1 gene was cloned by …