A synaptic basis for T-lymphocyte activation
MA Norcross - Annales de l'Institut Pasteur/Immunologie, 1984 - Elsevier
T lymphocytes respond to foreign antigen by forming specialized junctions with antigen-
presenting cells (APC) or target cells. A hypothesis is presented, illustrating the similarity
between the T-cell recognition-activation process and the cell communication processes
found in other organ systems, especially the nervous system. Based on data showing that a
major neuronal protein, Thy-1, is also a mitogenic site on T cells, and based on predictions
for the structures of the T-cell receptor (TcR) and Ia proteins, an activation model is …
presenting cells (APC) or target cells. A hypothesis is presented, illustrating the similarity
between the T-cell recognition-activation process and the cell communication processes
found in other organ systems, especially the nervous system. Based on data showing that a
major neuronal protein, Thy-1, is also a mitogenic site on T cells, and based on predictions
for the structures of the T-cell receptor (TcR) and Ia proteins, an activation model is …