[HTML][HTML] Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1
MF Yueh, YH Huang, A Hiller, S Chen… - Journal of Biological …, 2003 - ASBMB
UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an important physiological role by
contributing to the metabolism of endogenous substances such as bilirubin in addition to
xenobiotics and drugs. The UGT1A1 gene has been shown to be inducible by nuclear
receptors steroid xenobiotic receptor (SXR) and the constitutive active receptor, CAR. In this
report, we show that in human hepatoma HepG2 cells the UGT1A1 gene is also inducible
with aryl hydrocarbon receptor (Ah receptor) ligands such as 2, 3, 7, 8-tetrachlodibenzo-p …
contributing to the metabolism of endogenous substances such as bilirubin in addition to
xenobiotics and drugs. The UGT1A1 gene has been shown to be inducible by nuclear
receptors steroid xenobiotic receptor (SXR) and the constitutive active receptor, CAR. In this
report, we show that in human hepatoma HepG2 cells the UGT1A1 gene is also inducible
with aryl hydrocarbon receptor (Ah receptor) ligands such as 2, 3, 7, 8-tetrachlodibenzo-p …