Nitric oxide stimulates prostaglandin synthesis in cultured rabbit gastric cells
H Uno, T Arakawa, T Fukuda, H Yu, Y Fujiwara… - Prostaglandins, 1997 - Elsevier
Both prostaglandins (PGs) and nitric oxide (NO) have cytoprotective and hyperemic effects
in the stomach. However, the effect of NO on PG synthesis in gastric mucosal cells is
unclear. We examined whether sodium nitroprusside (SNP), a releaser of NO, stimulates PG
synthesis in cultured rabbit gastric mucus-producing cells. These cells did not release NO
themselves. Co-incubation with SNP (2× 10− 4, 5× 10− 4, 10− 3 M) increased PGE2
synthesis, and SNP (10− 3 M) increased PGI2 synthesis in these cells. Hemoglobin, a …
in the stomach. However, the effect of NO on PG synthesis in gastric mucosal cells is
unclear. We examined whether sodium nitroprusside (SNP), a releaser of NO, stimulates PG
synthesis in cultured rabbit gastric mucus-producing cells. These cells did not release NO
themselves. Co-incubation with SNP (2× 10− 4, 5× 10− 4, 10− 3 M) increased PGE2
synthesis, and SNP (10− 3 M) increased PGI2 synthesis in these cells. Hemoglobin, a …