Nitric oxide donors increase mucus gel thickness in rat stomach
JF Brown, PJ Hanson, BJR Whittle - European journal of pharmacology, 1992 - Elsevier
JF Brown, PJ Hanson, BJR Whittle
European journal of pharmacology, 1992•ElsevierInstillation of the nitric oxide (NO) generator isosorbide dinitrute (0.1–1 mM) into the nit
gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was
prevented by coadministration of oxyhaemoglobin (10 μM). Isosorbide dinitrate did not
induce epithelial cell damage. S-Nitroso-N-acetyl-penicillamine (0.3 mM) and dihutyryl cyclic
GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO
synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus …
gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was
prevented by coadministration of oxyhaemoglobin (10 μM). Isosorbide dinitrate did not
induce epithelial cell damage. S-Nitroso-N-acetyl-penicillamine (0.3 mM) and dihutyryl cyclic
GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO
synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus …
Abstract
Instillation of the nitric oxide (NO) generator isosorbide dinitrute (0.1–1 mM) into the nit gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was prevented by coadministration of oxyhaemoglobin (10 μM). Isosorbide dinitrate did not induce epithelial cell damage. S-Nitroso-N-acetyl-penicillamine (0.3 mM) and dihutyryl cyclic GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus release.
Elsevier