The role of calbindin and 1, 25dihydroxyvitamin D3 in the kidney

K Sooy, J Kohut, S Christakos - Current opinion in nephrology and …, 2000 - journals.lww.com
Current opinion in nephrology and hypertension, 2000journals.lww.com
The identification of a putative apical Ca++ channel in 1, 25dihydroxyvitamin D 3 responsive
epithelia (proximal intestine and the distal nephron) as well as recent studies using
calbindin-D 28k knock-out mice indicating the first direct in-vivo evidence for a role for this
calcium-binding protein in renal calcium absorption suggest mechanisms, which had
remained incomplete, related to the control of renal calcium absorption.
Abstract
The identification of a putative apical Ca++ channel in 1, 25dihydroxyvitamin D 3 responsive epithelia (proximal intestine and the distal nephron) as well as recent studies using calbindin-D 28k knock-out mice indicating the first direct in-vivo evidence for a role for this calcium-binding protein in renal calcium absorption suggest mechanisms, which had remained incomplete, related to the control of renal calcium absorption.
Lippincott Williams & Wilkins