P2 purinoceptor saturation by adenosine triphosphate impairs renal autoregulation in dogs
DSA MAJID, EW INSCHO… - Journal of the American …, 1999 - journals.lww.com
Recent studies have suggested a role for P2 purinoceptors on vascular smooth muscle cells
in the mechanism of renal autoregulation. Experiments were performed in anesthetized
dogs (n= 9) to examine renal blood flow (RBF) auto-regulatory efficiency before and after
saturation of P2 purinoceptors with acute intra-arterial administration of ATP (1 mg/kg per
min). Dogs were pretreated with the nitric oxide synthase inhibitor nitro-L-arginine (NLA)(50
μg/kg per min), to avoid endothelial P2 receptor-mediated effects on nitric oxide release …
in the mechanism of renal autoregulation. Experiments were performed in anesthetized
dogs (n= 9) to examine renal blood flow (RBF) auto-regulatory efficiency before and after
saturation of P2 purinoceptors with acute intra-arterial administration of ATP (1 mg/kg per
min). Dogs were pretreated with the nitric oxide synthase inhibitor nitro-L-arginine (NLA)(50
μg/kg per min), to avoid endothelial P2 receptor-mediated effects on nitric oxide release …