[HTML][HTML] Key role of a downstream specificity protein 1 site in cell cycle-regulated transcription of the AP endonuclease gene APE1/APEX in NIH3T3 cells
H Fung, RAO Bennett, B Demple - Journal of Biological Chemistry, 2001 - ASBMB
Abasic (apurinic/apyrimidinic or AP) sites are a frequent type of DNA damage that threatens
genetic stability. The predominant mammalian enzyme initiating repair of AP sites is the
Ape1 AP endonuclease (also called Apex or Hap1), which also facilitates DNA binding by
several transcription factors (Ref1 activity). We found that expression of the APE1 gene was
coordinated with the cell cycle in murine NIH3T3 cells: APE1 mRNA levels rose after the G 1-
S transition and peaked∼ 4-fold higher in early to mid-S phase. The increased APE1 mRNA …
genetic stability. The predominant mammalian enzyme initiating repair of AP sites is the
Ape1 AP endonuclease (also called Apex or Hap1), which also facilitates DNA binding by
several transcription factors (Ref1 activity). We found that expression of the APE1 gene was
coordinated with the cell cycle in murine NIH3T3 cells: APE1 mRNA levels rose after the G 1-
S transition and peaked∼ 4-fold higher in early to mid-S phase. The increased APE1 mRNA …