The influence of DNA glycosylases on spontaneous mutation
BJ Glassner, LM Posnick, LD Samson - Mutation Research/Fundamental …, 1998 - Elsevier
It is ironic that the physiological conditions that sustain life are ultimately responsible for the
relentless generation of spontaneous DNA damage that, if left unattended, would kill the
organism. Membrane lipids unavoidably oxidize to produce DNA damaging species; energy
production via oxidative metabolism unavoidably releases DNA damaging reactive oxygen
species; numerous intermediary metabolites can inadvertently attack DNA; and the
temperature, pH and ionic strength of the DNA milieu prescribe a finite rate of DNA …
relentless generation of spontaneous DNA damage that, if left unattended, would kill the
organism. Membrane lipids unavoidably oxidize to produce DNA damaging species; energy
production via oxidative metabolism unavoidably releases DNA damaging reactive oxygen
species; numerous intermediary metabolites can inadvertently attack DNA; and the
temperature, pH and ionic strength of the DNA milieu prescribe a finite rate of DNA …