Polymorphic radiation sensitivity of human natural killer activity: possible role of DNA strand breakage
B Schacter, S Hansal, J Arno, MJ LeVine - Human immunology, 1985 - Elsevier
Natural killer (NK) activity of human mononuclear cells is sensitive to inhibition by radiation,
under the control of polymorphic X linked genes. In order to define the mechanism of this
inhibition, we have evaluated the ability of treatments known to damage DNA to inhibit NK
activity. The alkylating agents streptozotocin (SZ) and N-methyl-N′-nitro-N-
nitrosoguanidine (MNNG) were potent inhibitors of NK activity. Further, a specific competitive
inhibitor of adenosine diphosphoribosyl polymerase (ADPRP), 3-aminobenzamide, was …
under the control of polymorphic X linked genes. In order to define the mechanism of this
inhibition, we have evaluated the ability of treatments known to damage DNA to inhibit NK
activity. The alkylating agents streptozotocin (SZ) and N-methyl-N′-nitro-N-
nitrosoguanidine (MNNG) were potent inhibitors of NK activity. Further, a specific competitive
inhibitor of adenosine diphosphoribosyl polymerase (ADPRP), 3-aminobenzamide, was …