[HTML][HTML] Distinct mechanisms of α5β1 integrin activation by Ha-Ras and R-Ras
T Kinashi, K Katagiri, S Watanabe… - Journal of Biological …, 2000 - ASBMB
To investigate the possible roles of the Ras/Rho family members in the inside-out signals to
activate integrins, we examined the ability of Ras/Rho small GTPases to stimulate avidity of
α 5 β 1 (VLA-5) to fibronectin in bone marrow-derived mast cells. We found that both Ha-Ras
Val-12 and R-Ras Val-38 had strong stimulatory effects on adhesion and ligand binding
activity of VLA-5 to fibronectin. However, only Ha-Ras Val-12-, but not R-Ras Val-38-induced
adhesion was inhibited by wortmannin, which suggests that Ha-Ras Val-12 is dependent on …
activate integrins, we examined the ability of Ras/Rho small GTPases to stimulate avidity of
α 5 β 1 (VLA-5) to fibronectin in bone marrow-derived mast cells. We found that both Ha-Ras
Val-12 and R-Ras Val-38 had strong stimulatory effects on adhesion and ligand binding
activity of VLA-5 to fibronectin. However, only Ha-Ras Val-12-, but not R-Ras Val-38-induced
adhesion was inhibited by wortmannin, which suggests that Ha-Ras Val-12 is dependent on …