[HTML][HTML] Superoxide activates mitochondrial uncoupling protein 2 from the matrix side: studies using targeted antioxidants
Superoxide activates nucleotide-sensitive mitochondrial proton transport through the
uncoupling proteins UCP1, UCP2, and UCP3 (Echtay, KS, et al.(2002) Nature 415, 1482–
1486). Two possible mechanisms were proposed: direct activation of the UCP proton
transport mechanism by superoxide or its products and a cycle of hydroperoxyl radical entry
coupled to UCP-catalyzed superoxide anion export. Here we provide evidence for the first
mechanism and show that superoxide activates UCP2 in rat kidney mitochondria from the …
uncoupling proteins UCP1, UCP2, and UCP3 (Echtay, KS, et al.(2002) Nature 415, 1482–
1486). Two possible mechanisms were proposed: direct activation of the UCP proton
transport mechanism by superoxide or its products and a cycle of hydroperoxyl radical entry
coupled to UCP-catalyzed superoxide anion export. Here we provide evidence for the first
mechanism and show that superoxide activates UCP2 in rat kidney mitochondria from the …