[HTML][HTML] No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria
E Couplan, M del Mar Gonzalez-Barroso… - Journal of Biological …, 2002 - ASBMB
The phenotypes observed in mice whose uncoupling protein (Ucp2) gene had been
invalidated by homologous recombination (Ucp2 (−/−) mice) are consistent with an increase
in mitochondrial membrane potential in macrophages and pancreatic β cells. This could
support an uncoupling (proton transport) activity of UCP2 in the inner mitochondrial
membranein vivo. We used mitochondria from lung or spleen, the two organs expressing the
highest level of UCP2, to compare the proton leak of the mitochondrial inner membrane of …
invalidated by homologous recombination (Ucp2 (−/−) mice) are consistent with an increase
in mitochondrial membrane potential in macrophages and pancreatic β cells. This could
support an uncoupling (proton transport) activity of UCP2 in the inner mitochondrial
membranein vivo. We used mitochondria from lung or spleen, the two organs expressing the
highest level of UCP2, to compare the proton leak of the mitochondrial inner membrane of …