What if Minkowski had been ageusic? An alternative angle on diabetes
JD McGarry - Science, 1992 - science.org
JD McGarry
Science, 1992•science.orgDespite decades of intensive investigation, the basic pathophysiological mechanisms
responsible for the metabolic derangements associated with diabetes mellitus have
remained elusive. Explored here is the possibility that traditional concepts in this area might
have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance
and hyperglycemia might be more readily understood if viewed in the context of underlying
abnormalities of lipid metabolism.
responsible for the metabolic derangements associated with diabetes mellitus have
remained elusive. Explored here is the possibility that traditional concepts in this area might
have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance
and hyperglycemia might be more readily understood if viewed in the context of underlying
abnormalities of lipid metabolism.
Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance and hyperglycemia might be more readily understood if viewed in the context of underlying abnormalities of lipid metabolism.
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