[HTML][HTML] Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses
RW Sobol, M Kartalou, KH Almeida, DF Joyce… - Journal of Biological …, 2003 - ASBMB
DNA alkylation damage is primarily repaired by the base excision repair (BER) machinery in
mammalian cells. In repair of the N-alkylated purine base lesion, for example, alkyl adenine
DNA glycosylase (Aag) recognizes and removes the base, and DNA polymerase β (β-pol)
contributes the gap tailoring and DNA synthesis steps. It is the loss of β-pol-mediated 5′-
deoxyribose phosphate removal that renders mouse fibroblasts alkylation-hypersensitive.
Here we report that the hypersensitivity of β-pol-deficient cells after methyl methanesulfonate …
mammalian cells. In repair of the N-alkylated purine base lesion, for example, alkyl adenine
DNA glycosylase (Aag) recognizes and removes the base, and DNA polymerase β (β-pol)
contributes the gap tailoring and DNA synthesis steps. It is the loss of β-pol-mediated 5′-
deoxyribose phosphate removal that renders mouse fibroblasts alkylation-hypersensitive.
Here we report that the hypersensitivity of β-pol-deficient cells after methyl methanesulfonate …