Defective DNA polymerase-δ proofreading causes cancer susceptibility in mice
RE Goldsby, NA Lawrence, LE Hays, EA Olmsted… - Nature medicine, 2001 - nature.com
RE Goldsby, NA Lawrence, LE Hays, EA Olmsted, X Chen, M Singh, BD Preston
Nature medicine, 2001•nature.comFig. 1 Reduced survival and increased tumor incidence in Pold1D400A/D400A mice. a,
Kaplan-Meier survival estimates (P< 0.0001 by log-rank and Wilcoxon tests; JMP IN 3.2. 1
software, SAS Institute, Inc.)., dead animals; tic marks above each curve, animals still alive;
each symbol represents one or more mice. 2 of the 97 Pold1+/D400A heterozygotes died of
unknown causes; no tumors were evident. b, Tumor incidence by genotype.'n', number of
mice; Lymph, lymphoblastic lymphoma; SCC, squamous-cell carcinoma of the …
Kaplan-Meier survival estimates (P< 0.0001 by log-rank and Wilcoxon tests; JMP IN 3.2. 1
software, SAS Institute, Inc.)., dead animals; tic marks above each curve, animals still alive;
each symbol represents one or more mice. 2 of the 97 Pold1+/D400A heterozygotes died of
unknown causes; no tumors were evident. b, Tumor incidence by genotype.'n', number of
mice; Lymph, lymphoblastic lymphoma; SCC, squamous-cell carcinoma of the …
Fig. 1 Reduced survival and increased tumor incidence in Pold1D400A/D400A mice. a, Kaplan-Meier survival estimates (P< 0.0001 by log-rank and Wilcoxon tests; JMP IN 3.2. 1 software, SAS Institute, Inc.)., dead animals; tic marks above each curve, animals still alive; each symbol represents one or more mice. 2 of the 97 Pold1+/D400A heterozygotes died of unknown causes; no tumors were evident. b, Tumor incidence by genotype.‘n’, number of mice; Lymph, lymphoblastic lymphoma; SCC, squamous-cell carcinoma of the skin.‘Other’includes a fibrosarcoma, a metastatic histiocytic sarcoma and a papillary adenocarcinoma of the lung. a b
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