The cellular signals that lead to activation of suppressor T cells (Ts) as opposed to cytotoxic
T cells (CTL) are unknown. This review describes an in vitro suppressor-induction system
developed by us to characterize interactions among various T cells leading to the
development of antigen-specific suppression. In this system, antigen-specific CD4+ inducer
T cells are first activated with antigen-presenting cells (APC). Antigen-primed CD4+ inducer
blasts are then cultured with fresh autologous CD8+ T cells in the absence of the priming …